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Target
Cathepsin K
Ligand
BDBM50463229
Substrate
n/a
Meas. Tech.
ChEMBL_1777933 (CHEMBL4234925)
IC50
100±n/a nM
Citation
 Tber, Z; Wartenberg, M; Jacques, JE; Roy, V; Lecaille, F; Warszycki, D; Bojarski, AJ; Lalmanach, G; Agrofoglio, LA Selective inhibition of human cathepsin S by 2,4,6-trisubstituted 1,3,5-triazine analogs. Bioorg Med Chem 26:4310-4319 (2018) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50463229
Synonyms:
CHEMBL4243256
Type:
Small organic molecule
Emp. Form.:
C16H16F3N7O
Mol. Mass.:
379.3397
SMILES:
FC(F)(F)Oc1ccc(Nc2nc(NC3CCNCC3)nc(n2)C#N)cc1
Structure:
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