Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50467823
Substrate
n/a
Meas. Tech.
ChEMBL_1797057 (CHEMBL4269174)
IC50
3190±n/a nM
Citation
 Ashraf, AEjaz, SARahman, SUSiddiqui, WAArshad, MNLecka, JSévigny, JZayed, MEMAsiri, AMIqbal, JHartinger, CGHanif, M Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes. Eur J Med Chem 159:282-291 (2018) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM50467823
Synonyms:
CHEMBL4279425
Type:
Small organic molecule
Emp. Form.:
C15H10FNO3S
Mol. Mass.:
303.308
SMILES:
Fc1cccc(\C=C2/NS(=O)(=O)c3ccccc3C2=O)c1
Structure:
Search PDB for entries with ligand similarity: