Reaction Details
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Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50467827
Substrate
n/a
Meas. Tech.
ChEMBL_1797057 (CHEMBL4269174)
IC50
>200000±n/a nM
Citation
Ashraf, A; Ejaz, SA; Rahman, SU; Siddiqui, WA; Arshad, MN; Lecka, J; Sévigny, J; Zayed, MEM; Asiri, AM; Iqbal, J; Hartinger, CG; Hanif, M Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes. Eur J Med Chem 159:282-291 (2018) [PubMed] Article More Info.:
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
tissue-nonspecific alkaline phosphatase precursor | PPBT_HUMAN | ALPL
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Human
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
Inhibitor
Name:
BDBM50467827
Synonyms:
CHEMBL4287345
Type:
Small organic molecule
Emp. Form.:
C15H9Cl2NO3S
Mol. Mass.:
354.21
SMILES:
Clc1ccc(\C=C2/NS(=O)(=O)c3ccccc3C2=O)c(Cl)c1
Structure:
