Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50467818
Substrate
n/a
Meas. Tech.
ChEMBL_1797057 (CHEMBL4269174)
IC50
>200000±n/a nM
Citation
 Ashraf, AEjaz, SARahman, SUSiddiqui, WAArshad, MNLecka, JSévigny, JZayed, MEMAsiri, AMIqbal, JHartinger, CGHanif, M Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes. Eur J Med Chem 159:282-291 (2018) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM50467818
Synonyms:
CHEMBL4280348
Type:
Small organic molecule
Emp. Form.:
C15H10BrNO3S
Mol. Mass.:
364.214
SMILES:
Brc1ccccc1\C=C1/NS(=O)(=O)c2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity: