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Target
Prostaglandin E synthase
Ligand
BDBM50468870
Substrate
n/a
Meas. Tech.
ChEMBL_1801304 (CHEMBL4273596)
IC50
700±n/a nM
Citation
 Cheung, SY; Werner, M; Esposito, L; Troisi, F; Cantone, V; Liening, S; König, S; Gerstmeier, J; Koeberle, A; Bilancia, R; Rizza, R; Rossi, A; Roviezzo, F; Temml, V; Schuster, D; Stuppner, H; Schubert-Zsilavecz, M; Werz, O; Hanke, T; Pace, S Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E Eur J Med Chem 156:815-830 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
Prostaglandin E2 synthase-1 ( mPGES-1) | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | PTGES_HUMAN | PTGES | MGST1L1 | MPGES1 | PGES | PIG12 | Prostaglandin E synthase/G/H synthase 2
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Human
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50468870
Synonyms:
CHEMBL4278377
Type:
Small organic molecule
Emp. Form.:
C32H27NO4S
Mol. Mass.:
521.64
SMILES:
OC(=O)CCc1ccc(cc1)N(Cc1ccc2ccccc2c1)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Structure:
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