Reaction Details Report a problem with these data
Target
Type-1/Type-2 angiotensin II receptor
Ligand
BDBM50047126
Substrate
n/a
Meas. Tech.
ChEMBL_36177 (CHEMBL649491)
IC50
5.0±n/a nM
Citation
  TBA Bioorg Med Chem Lett 4:139-144 (1994)    Article 
Target
Name:
Type-1/Type-2 angiotensin II receptor
Synonyms:
Angiotensin II receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 357784
Components:
This complex has 2 components.
Component 1
Name:
Type-1 angiotensin II receptor
Synonyms:
Angiotensin II AT1 | Angiotensin II type 1b (AT-1b) receptor | AT1 | Angiotensin II receptor | AT1BR | AT1AR | Type-1 angiotensin II receptor (AT1) | AGTR1_HUMAN | AGTR1 | AGTR1A | AGTR1B | AT2R1 | AT2R1B
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Human
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Component 2
Name:
Type-2 angiotensin II receptor
Synonyms:
Angiotensin II receptor | AT2 | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | AGTR2_HUMAN | AGTR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Human
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50047126
Synonyms:
2-Ethyl-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-5,6,7,8-tetrahydro-quinoline | ZD-6888 | 2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-5,6,7,8-tetrahydro-quinoline | CHEMBL418226
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCc1cc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2CCCCc2n1
Structure:
Search PDB for entries with ligand similarity: