Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50472196
Substrate
n/a
Meas. Tech.
ChEMBL_155726 (CHEMBL760760)
IC50
6000±n/a nM
Citation
 Christensen, SBGuider, AForster, CJGleason, JGBender, PEKarpinski, JMDeWolf, WEBarnette, MSUnderwood, DCGriswold, DECieslinski, LBBurman, MBochnowicz, SOsborn, RRManning, CDGrous, MHillegas, LMBartus, JORyan, MDEggleston, DSHaltiwanger, RCTorphy, TJ 1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma. J Med Chem 41:821-35 (1998) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rat
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50472196
Synonyms:
CHEMBL354656
Type:
Small organic molecule
Emp. Form.:
C19H25FO3
Mol. Mass.:
320.3984
SMILES:
COc1ccc(cc1OC1CCCC1)C1(CF)CCC(=O)CC1
Structure:
Search PDB for entries with ligand similarity: