Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Ligand
BDBM50472806
Substrate
n/a
Meas. Tech.
ChEMBL_152460 (CHEMBL761449)
IC50
39±n/a nM
Citation
 Aicher, TDAnderson, RCGao, JShetty, SSCoppola, GMStanton, JLKnorr, DCSperbeck, DMBrand, LJVinluan, CCKaplan, ELDragland, CJTomaselli, HCIslam, ALozito, RJLiu, XManiara, WMFillers, WSDelGrande, DWalter, REMann, WR Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase. J Med Chem 43:236-49 (2000) [PubMed]  Article 
Target
Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Synonyms:
2.7.11.2 | PDK4_RAT | Pdk4 | Pyruvate dehydrogenase kinase isoform 4 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Type:
PROTEIN
Mol. Mass.:
46681.07
Organism:
Rattus norvegicus
Description:
ChEMBL_104818
Residue:
412
Sequence:
MKAARFVMRSASSLGNAGLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFSFLRQELPVRLANILKEIDILPEHLVNTPSVQLVKSWYIQSLMDLVEFHEKSPEDQKVLSDFVDTLVKVRNRHHNVVPTMAQGILEYKDNCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSIDPNCDVVAVVEDAFECAKMLCDQYYLTSPELKLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENRPFLTPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSKEPKNLSKEKLAV
  
Inhibitor
Name:
BDBM50472806
Synonyms:
CHEMBL84406
Type:
Small organic molecule
Emp. Form.:
C24H29F3N2O4S
Mol. Mass.:
498.558
SMILES:
C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)-c1c(C)cc(C)cc1C)C(=O)[C@@](C)(O)C(F)(F)F
Structure:
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