Reaction Details Report a problem with these data
Target
Substance-K receptor
Ligand
BDBM50472913
Substrate
n/a
Meas. Tech.
ChEMBL_209209 (CHEMBL818003)
Ki
20±n/a nM
Citation
 Giannotti, D; Perrotta, E; Di Bugno, C; Nannicini, R; Harmat, NJ; Giolitti, A; Patacchini, R; Renzetti, AR; Rotondaro, L; Giuliani, S; Altamura, M; Maggi, CA Discovery of potent cyclic pseudopeptide human tachykinin NK-2 receptor antagonists. J Med Chem 43:4041-4 (2000) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50472913
Synonyms:
CHEMBL2112675
Type:
Small organic molecule
Emp. Form.:
C34H34F3N5O4
Mol. Mass.:
633.6601
SMILES:
FC(F)(F)c1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1
Structure:
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