Reaction Details
Report a problem with these data
Report a problem with these dataTarget
C-X-C chemokine receptor type 1/2
Ligand
BDBM50088570
Substrate
n/a
Meas. Tech.
ChEMBL_312518 (CHEMBL833397)
IC50
50±n/a nM
Citation
Allegretti, M; Bertini, R; Cesta, MC; Bizzarri, C; Di Bitondo, R; Di Cioccio, V; Galliera, E; Berdini, V; Topai, A; Zampella, G; Russo, V; Di Bello, N; Nano, G; Nicolini, L; Locati, M; Fantucci, P; Florio, S; Colotta, F 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem 48:4312-31 (2005) [PubMed] Article More Info.:
Target
Name:
C-X-C chemokine receptor type 1/2
Synonyms:
Interleukin-8 receptors, CXCR1/CXCR2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 89096
Components:
This complex has 2 components.
Component 1
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 | CXCR1_HUMAN | CXCR1 | CMKAR1 | IL8RA
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Human
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
Component 2
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | CDw128b | CXCR-2 | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | Interleukin-8 receptor B | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CXCR2_HUMAN | CXCR2 | IL8RB
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Human
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
Inhibitor
Name:
BDBM50088570
Synonyms:
2-(3-Benzoyl-phenyl)-propionic acid | (S)-2-(3-benzoylphenyl)propanoic acid | CHEMBL75435 | (S)-2-(3-Benzoyl-phenyl)-propionic acid | KETOPROFEN
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@@H](c1cccc(c1)C(=O)c2ccccc2)C(=O)O
Structure:
