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Target
Substance-K receptor
Ligand
BDBM50476793
Substrate
n/a
Meas. Tech.
ChEMBL_446257 (CHEMBL895361)
Ki
0.131826±n/a nM
Citation
 Fedi, V; Altamura, M; Catalioto, RM; Giannotti, D; Giolitti, A; Giuliani, S; Guidi, A; Harmat, NJ; Lecci, A; Meini, S; Nannicini, R; Pasqui, F; Tramontana, M; Triolo, A; Maggi, CA Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists. J Med Chem 50:4793-807 (2007) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50476793
Synonyms:
CHEMBL394780
Type:
Small organic molecule
Emp. Form.:
C31H40N6O5S2
Mol. Mass.:
640.817
SMILES:
NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC(=O)c2cc3ccccc3s2)CC1
Structure:
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