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Target
D(1A) dopamine receptor
Ligand
BDBM50477152
Substrate
n/a
Meas. Tech.
ChEMBL_449891 (CHEMBL898995)
Ki
0.642688±n/a nM
Citation
 Chakrabarty, R; Rao, J; Anand, A; Roy, AD; Roy, R; Shankar, G; Dua, PR; Saxena, AK Rational design, synthesis and evaluation of (6aR( *),11bS( *))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent. Bioorg Med Chem 15:7361-7 (2007) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50477152
Synonyms:
CHEMBL393466
Type:
Small organic molecule
Emp. Form.:
C34H37F2N3O2
Mol. Mass.:
557.6733
SMILES:
Fc1ccc(cc1)C(=O)CCCN1C2CN3CCN(CCCC(=O)c4ccc(F)cc4)CC3CC2c2ccccc12
Structure:
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