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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM50028160
Substrate
n/a
Meas. Tech.
ChEBML_192
IC50
7050±n/a nM
Citation
 Hays, SJ; Tobes, MC; Gildersleeve, DL; Wieland, DM; Beierwaltes, WH Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem 27:15-9 (1984) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_BOVIN | CYP11B1 | Cytochrome P450 11B1
Type:
PROTEIN
Mol. Mass.:
57863.81
Organism:
Bos taurus
Description:
ChEMBL_1345884
Residue:
503
Sequence:
MALWAKARVRMAGPWLSLHEARLLGTRGAAAPKAVLPFEAMPRCPGNKWMRMLQIWKEQSSENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQADSHHPQRMILEPWLAYRQARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQNARGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMLKSTVQLMFVPRRLSRWMSTNMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRADMTLDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQAVRQESLVAEARISENPQRAITELPLLRAALKETLRLYPVGITLEREVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARPESYHPQRWLDRQGSGSRFPHLAFGFGVRQCLGRRVAEVEMLLLLHHVLKNFLVETLEQEDIKMVYRFILMPSTLPLFTFRAIQ
  
Inhibitor
Name:
BDBM50028160
Synonyms:
2-Methyl-1,2-di-pyridin-3-yl-propan-1-ol | 2-methyl-1,2-di(pyridin-3-yl)propan-1-ol | CHEMBL933 | METYRAPOL | Metyrapol (MPOL)
Type:
Small organic molecule
Emp. Form.:
C14H16N2O
Mol. Mass.:
228.2896
SMILES:
CC(C)(C(O)c1cccnc1)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: