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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50144841
Substrate
n/a
Meas. Tech.
ChEMBL_460518 (CHEMBL926598)
EC50
50±n/a nM
Citation
 Smith, BM; Smith, JM; Tsai, JH; Schultz, JA; Gilson, CA; Estrada, SA; Chen, RR; Park, DM; Prieto, EB; Gallardo, CS; Sengupta, D; Dosa, PI; Covel, JA; Ren, A; Webb, RR; Beeley, NR; Martin, M; Morgan, M; Espitia, S; Saldana, HR; Bjenning, C; Whelan, KT; Grottick, AJ; Menzaghi, F; Thomsen, WJ Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. J Med Chem 51:305-13 (2008) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50144841
Synonyms:
(S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine | (S)-2-(6-Chloro-5-fluoro-indol-1-yl)-1-methyl-ethylamine | CHEMBL76781 | Ro-60-0175 | Ro-600175
Type:
Small organic molecule
Emp. Form.:
C11H12ClFN2
Mol. Mass.:
226.678
SMILES:
C[C@H](N)Cn1ccc2cc(F)c(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: