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Target
Reverse transcriptase
Ligand
BDBM50478100
Substrate
n/a
Meas. Tech.
ChEMBL_468352 (CHEMBL931815)
IC50
1900±n/a nM
Citation
 Boojamra, CG; Mackman, RL; Markevitch, DY; Prasad, V; Ray, AS; Douglas, J; Grant, D; Kim, CU; Cihlar, T Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor. Bioorg Med Chem Lett 18:1120-3 (2008) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50478100
Synonyms:
CHEMBL252036 | GS-9148
Type:
Small organic molecule
Emp. Form.:
C10H11FN5O5P
Mol. Mass.:
331.197
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](OCP(O)(O)=O)C=C1F |r,c:21|
Structure:
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