Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50467780
Substrate
n/a
Meas. Tech.
ChEMBL_1804551 (CHEMBL4303775)
Ki
4786±n/a nM
Citation
 Gordon, DEJang, GMBouhaddou, MXu, JObernier, KWhite, KMO'Meara, MJRezelj, VVGuo, JZSwaney, DLTummino, TAHüttenhain, RKaake, RMRichards, ALTutuncuoglu, BFoussard, HBatra, JHaas, KModak, MKim, MHaas, PPolacco, BJBraberg, HFabius, JMEckhardt, MSoucheray, MBennett, MJCakir, MMcGregor, MJLi, QMeyer, BRoesch, FVallet, TMac Kain, AMiorin, LMoreno, ENaing, ZZCZhou, YPeng, SShi, YZhang, ZShen, WKirby, ITMelnyk, JEChorba, JSLou, KDai, SABarrio-Hernandez, IMemon, DHernandez-Armenta, CLyu, JMathy, CJPPerica, TPilla, KBGanesan, SJSaltzberg, DJRakesh, RLiu, XRosenthal, SBCalviello, LVenkataramanan, SLiboy-Lugo, JLin, YHuang, XPLiu, YWankowicz, SABohn, MSafari, MUgur, FSKoh, CSavar, NSTran, QDShengjuler, DFletcher, SJO'Neal, MCCai, YChang, JCJBroadhurst, DJKlippsten, SSharp, PPWenzell, NAKuzuoglu-Ozturk, DWang, HYTrenker, RYoung, JMCavero, DAHiatt, JRoth, TLRathore, USubramanian, ANoack, JHubert, MStroud, RMFrankel, ADRosenberg, OSVerba, KAAgard, DAOtt, MEmerman, MJura, Nvon Zastrow, MVerdin, EAshworth, ASchwartz, Od'Enfert, CMukherjee, SJacobson, MMalik, HSFujimori, DGIdeker, TCraik, CSFloor, SNFraser, JSGross, JDSali, ARoth, BLRuggero, DTaunton, JKortemme, TBeltrao, PVignuzzi, MGarcía-Sastre, AShokat, KMShoichet, BKKrogan, NJ A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583:459-468 (2020) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50467780
Synonyms:
CHEBI:5801 | Hydroxychloroquine | acs.jmedchem.1c00409_ST.817 | med.21724, Compound 9
Type:
Small organic molecule
Emp. Form.:
C18H26ClN3O
Mol. Mass.:
335.872
SMILES:
CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: