Target
Potassium voltage-gated channel subfamily H member 2
Ligand
BDBM50253157
Substrate
n/a
Meas. Tech.
ChEMBL_1804555 (CHEMBL4303779)
Ki
158±n/a nM
Citation
 Gordon, DEJang, GMBouhaddou, MXu, JObernier, KWhite, KMO'Meara, MJRezelj, VVGuo, JZSwaney, DLTummino, TAHüttenhain, RKaake, RMRichards, ALTutuncuoglu, BFoussard, HBatra, JHaas, KModak, MKim, MHaas, PPolacco, BJBraberg, HFabius, JMEckhardt, MSoucheray, MBennett, MJCakir, MMcGregor, MJLi, QMeyer, BRoesch, FVallet, TMac Kain, AMiorin, LMoreno, ENaing, ZZCZhou, YPeng, SShi, YZhang, ZShen, WKirby, ITMelnyk, JEChorba, JSLou, KDai, SABarrio-Hernandez, IMemon, DHernandez-Armenta, CLyu, JMathy, CJPPerica, TPilla, KBGanesan, SJSaltzberg, DJRakesh, RLiu, XRosenthal, SBCalviello, LVenkataramanan, SLiboy-Lugo, JLin, YHuang, XPLiu, YWankowicz, SABohn, MSafari, MUgur, FSKoh, CSavar, NSTran, QDShengjuler, DFletcher, SJO'Neal, MCCai, YChang, JCJBroadhurst, DJKlippsten, SSharp, PPWenzell, NAKuzuoglu-Ozturk, DWang, HYTrenker, RYoung, JMCavero, DAHiatt, JRoth, TLRathore, USubramanian, ANoack, JHubert, MStroud, RMFrankel, ADRosenberg, OSVerba, KAAgard, DAOtt, MEmerman, MJura, Nvon Zastrow, MVerdin, EAshworth, ASchwartz, Od'Enfert, CMukherjee, SJacobson, MMalik, HSFujimori, DGIdeker, TCraik, CSFloor, SNFraser, JSGross, JDSali, ARoth, BLRuggero, DTaunton, JKortemme, TBeltrao, PVignuzzi, MGarcía-Sastre, AShokat, KMShoichet, BKKrogan, NJ A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583:459-468 (2020) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily H member 2
Synonyms:
1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit
Type:
Multi-pass membrane protein
Mol. Mass.:
126672.65
Organism:
Homo sapiens (Human)
Description:
Q12809
Residue:
1159
Sequence:
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS
  
Inhibitor
Name:
BDBM50253157
Synonyms:
(+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine | (+)-(2R)-2-[2-[[(R)-p-chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine | (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine | CHEMBL1626 | CLEMASTINE
Type:
Small organic molecule
Emp. Form.:
C21H26ClNO
Mol. Mass.:
343.89
SMILES:
CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: