Target
Reverse transcriptase
Ligand
BDBM50479984
Substrate
n/a
Meas. Tech.
ChEMBL_543748 (CHEMBL1020339)
IC50
14500±n/a nM
Citation
 Frangeul, ABarral, KAlvarez, KCanard, B In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives. Antimicrob Agents Chemother 51:3162-7 (2007) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50479984
Synonyms:
CHEMBL2448398
Type:
Small organic molecule
Emp. Form.:
C9H17BN5O9P3
Mol. Mass.:
442.992
SMILES:
BP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(O)=O |r|
Structure:
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