Reaction Details Report a problem with these data
Target
Reverse transcriptase protein
Ligand
BDBM50480766
Substrate
n/a
Meas. Tech.
ChEMBL_583932 (CHEMBL1061783)
Kd
2990±n/a nM
Citation
 Zelina, S; Sheen, CW; Radzio, J; Mellors, JW; Sluis-Cremer, N Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine. Antimicrob Agents Chemother 52:157-63 (2008) [PubMed]  Article 
Target
Name:
Reverse transcriptase protein
Synonyms:
Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A)
Type:
Protein
Mol. Mass.:
30203.56
Organism:
Human immunodeficiency virus 1
Description:
Q9WJQ2
Residue:
259
Sequence:
PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWTVQPIVLPEKDSWTVNDIQK
  
Inhibitor
Name:
BDBM50480766
Synonyms:
2''-Deoxycytidine 5''-Triphosphate | CHEBI:16311 | Deoxycytidine Triphosphate
Type:
Small organic molecule
Emp. Form.:
C9H16N3O13P3
Mol. Mass.:
467.1569
SMILES:
Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1 |r|
Structure:
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