Reaction Details Report a problem with these data
Target
Dihydrofolate synthase/folylpolyglutamate synthase
Ligand
BDBM50482590
Substrate
n/a
Meas. Tech.
ChEMBL_650711 (CHEMBL1227291)
Ki
3100±n/a nM
Citation
 Kwon, YK; Lu, W; Melamud, E; Khanam, N; Bognar, A; Rabinowitz, JD A domino effect in antifolate drug action in Escherichia coli. Nat Chem Biol 4:602-8 (2008) [PubMed]  Article 
Target
Name:
Dihydrofolate synthase/folylpolyglutamate synthase
Synonyms:
6.3.2.12 | 6.3.2.17 | DHFS / FPGS | Dihydrofolate synthase/folylpolyglutamate synthase | Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase | Folylpolyglutamate synthetase | Tetrahydrofolylpolyglutamate synthase | FOLC_ECOLI | folC | dedC
Type:
PROTEIN
Mol. Mass.:
45399.09
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_109146
Residue:
422
Sequence:
MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSGGK
  
Inhibitor
Name:
BDBM50482590
Synonyms:
CHEBI:15633 | Dihydrofolic acid
Type:
Small organic molecule
Emp. Form.:
C19H21N7O6
Mol. Mass.:
443.42
SMILES:
Nc1nc(=O)c2N=C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]1 |r,t:6|
Structure:
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