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Target
Thymidine phosphorylase
Ligand
BDBM20079
Substrate
n/a
Meas. Tech.
ChEMBL_739793 (CHEMBL1762853)
IC50
36±n/a nM
Citation
 Rajabi, M; Mansell, D; Freeman, S; Bryce, RA Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase. Eur J Med Chem 46:1165-71 (2011) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TdRPase | TYPH_ECOLI | deoA | tpp | ttg | Thymidine Phosphorylase (TP)
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM20079
Synonyms:
5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione | 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione | CHEMBL65375 | TPI | Tipiracil | Lonsurf
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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