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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50029100
Substrate
n/a
Meas. Tech.
ChEMBL_152579 (CHEMBL759757)
IC50
300000±n/a nM
Citation
 Bondinell, WE; Chapin, FW; Girard, GR; Kaiser, C; Krog, AJ; Pavloff, AM; Schwartz, MS; Silvestri, JS; Vaidya, PD; Lam, BL; Wellman, GR; Pendleton, RG Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines. J Med Chem 23:506-11 (1980) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50029100
Synonyms:
2-(4-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL358967 | para-chloroamphetamine
Type:
Small organic molecule
Emp. Form.:
C9H12ClN
Mol. Mass.:
169.651
SMILES:
CC(N)Cc1ccc(Cl)cc1
Structure:
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