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Target
Endothelin-1 receptor
Ligand
BDBM50407575
Substrate
n/a
Meas. Tech.
ChEMBL_65814
IC50
330±n/a nM
Citation
 Fukami, T; Nagase, T; Fujita, K; Hayama, T; Niiyama, K; Mase, T; Nakajima, S; Fukuroda, T; Saeki, T; Nishikibe, M Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. J Med Chem 38:4309-24 (1995) [PubMed]  Article  BDB Entry
Target
Name:
Endothelin-1 receptor
Synonyms:
Endothelin receptor ET-A
Type:
PROTEIN
Mol. Mass.:
48707.29
Organism:
Sus scrofa
Description:
ChEMBL_65803
Residue:
427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
  
Inhibitor
Name:
BDBM50407575
Synonyms:
CHEMBL404763
Type:
Small organic molecule
Emp. Form.:
C30H42N6O7
Mol. Mass.:
598.6905
SMILES:
CC(C)C[C@H]1NC(=O)[C@@H](NC(=O)C(C)(C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C
Structure:
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