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Target
Voltage-dependent calcium channel alpha-1 subunit
Ligand
BDBM50488058
Substrate
n/a
Meas. Tech.
ChEMBL_920700 (CHEMBL3066980)
IC50
26±n/a nM
Citation
 Windley, MJ; Escoubas, P; Valenzuela, SM; Nicholson, GM A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus. Mol Pharmacol 80:1-13 (2011) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel alpha-1 subunit
Synonyms:
Voltage-dependent calcium channel alpha-1 subunit
Type:
PROTEIN
Mol. Mass.:
99875.60
Organism:
German cockroach
Description:
ChEMBL_106597
Residue:
871
Sequence:
LFGGKFDFNNTVDKPRSNFDSFWQSLLTVFQILTGEDWNAVMYVGIQAYGGVSSIGVLACVYFIILFICGNYILLNVFLAIAVDNLADAESLTAIEKEAEEEAEKQQKSHSGSPAREEGQPEEGEGGEEPEKGLVNETENLEKEETESETKVPLEHGDSEDYQYHYEEHTDNQEEEEDEDHREPKSTARPRNVGDQPENNDSSTPEGSAFFIFSNTNRIRVFCHWLCNHSYFGNMILACIMISSAMLAAEEPLRAETPRNEILGKFDIFFTSVFTIEICLKMISYGFVLHDGAFCRSAFNLLDMLVVFVSLIAMFIRGSAISVIKILRVMRVLRPLRTINRAKGLKHVVQCVIVAVKTIGNIVLVTCLVQFMFAVIGVQLFKGKFFRCSDGSKMTEAECHGTYLVFDDGDINQPEVEERRWTRNRFHFDDVAKAMLTLFTVSTFEGWPGLLYVSIDSHDEDEGPIHNFRPIVAIFFIVYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPVRRYIPKHRIQYKVWWFVTSQPFEYTIFILIMLNTITLAMKFYNQPKYYEDFLDVLNIIFTAVFAMEFVFKLAAFRFKNYFGNAWNVFDFIIVLGSFIDIIYSEVNTPTRLKPGSGMISINFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALDSGTAIHRNNNFQTFPQAVLLLFRSATGEAWQDIMLDGSARDGVRCDSESDEKDKPICGSDMAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRVACKRLVSMNMPL
  
Inhibitor
Name:
BDBM50488058
Synonyms:
CHEMBL2272095
Type:
Small organic molecule
Emp. Form.:
C160H233N39O47S7
Mol. Mass.:
3679.32
SMILES:
CSCC[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC3=O)[C@@H](C)O)C(=O)N2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure:
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