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Target
Voltage-dependent calcium channel alpha-1 subunit
Ligand
BDBM50488057
Substrate
n/a
Meas. Tech.
ChEMBL_920701 (CHEMBL3066981)
IC50
25±n/a nM
Citation
 Windley, MJ; Escoubas, P; Valenzuela, SM; Nicholson, GM A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus. Mol Pharmacol 80:1-13 (2011) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel alpha-1 subunit
Synonyms:
Voltage-dependent calcium channel alpha-1 subunit
Type:
PROTEIN
Mol. Mass.:
99875.60
Organism:
German cockroach
Description:
ChEMBL_106597
Residue:
871
Sequence:
LFGGKFDFNNTVDKPRSNFDSFWQSLLTVFQILTGEDWNAVMYVGIQAYGGVSSIGVLACVYFIILFICGNYILLNVFLAIAVDNLADAESLTAIEKEAEEEAEKQQKSHSGSPAREEGQPEEGEGGEEPEKGLVNETENLEKEETESETKVPLEHGDSEDYQYHYEEHTDNQEEEEDEDHREPKSTARPRNVGDQPENNDSSTPEGSAFFIFSNTNRIRVFCHWLCNHSYFGNMILACIMISSAMLAAEEPLRAETPRNEILGKFDIFFTSVFTIEICLKMISYGFVLHDGAFCRSAFNLLDMLVVFVSLIAMFIRGSAISVIKILRVMRVLRPLRTINRAKGLKHVVQCVIVAVKTIGNIVLVTCLVQFMFAVIGVQLFKGKFFRCSDGSKMTEAECHGTYLVFDDGDINQPEVEERRWTRNRFHFDDVAKAMLTLFTVSTFEGWPGLLYVSIDSHDEDEGPIHNFRPIVAIFFIVYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPVRRYIPKHRIQYKVWWFVTSQPFEYTIFILIMLNTITLAMKFYNQPKYYEDFLDVLNIIFTAVFAMEFVFKLAAFRFKNYFGNAWNVFDFIIVLGSFIDIIYSEVNTPTRLKPGSGMISINFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALDSGTAIHRNNNFQTFPQAVLLLFRSATGEAWQDIMLDGSARDGVRCDSESDEKDKPICGSDMAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRVACKRLVSMNMPL
  
Inhibitor
Name:
BDBM50488057
Synonyms:
CHEMBL2272096
Type:
Small organic molecule
Emp. Form.:
C155H234N42O43S8
Mol. Mass.:
3630.36
SMILES:
CSCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |r|
Structure:
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