Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid type B receptor subunit 1/2
Ligand
BDBM24189
Substrate
n/a
Meas. Tech.
ChEMBL_68560 (CHEMBL679647)
IC50
45±n/a nM
Citation
 Froestl, W; Mickel, SJ; Hall, RG; von Sprecher, G; Strub, D; Baumann, PA; Brugger, F; Gentsch, C; Jaekel, J; Olpe, HR Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem 38:3297-312 (1995) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid type B receptor subunit 1/2
Synonyms:
GABA B receptor | GABA-B receptor 1/2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 68556
Components:
This complex has 2 components.
Component 1
Name:
Gamma-aminobutyric acid (GABA) B receptor 1
Synonyms:
GABA B | GABA B receptor | GABA uptake | GABA-B receptor 1 | GABA-B-R1 | GABA-BR1 | GABABR1 | GABR1_RAT | Gabbr1 | Gamma-aminobutyric acid type B receptor subunit 1 | Gamma-aminobutyric acid type B receptor subunit 1 (GABA) | Gb1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
108221.06
Organism:
Rat
Description:
Q6MFX8
Residue:
960
Sequence:
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
  
Component 2
Name:
Gamma-aminobutyric acid type B receptor subunit 2
Synonyms:
GABA B receptor | GABR2_RAT | Gabbr2 | Gpr51
Type:
PROTEIN
Mol. Mass.:
105775.46
Organism:
Rat
Description:
O88871
Residue:
940
Sequence:
MASPPSSGQPRPPPPPPPPARLLLPLLLSLLLWLAPGAWGWTRGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHFRWRRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAFEESMFGSKYQWIIPGWYEPAWWEQVHVEANSSRCLRRSLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQFEREYNSKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGKIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVERYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILSLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
  
Inhibitor
Name:
BDBM24189
Synonyms:
3-aminopropylphosphinic derivative, (R)-4 | 3-aminopropylphosphinic derivative, (S)-4 | CGP44532 | CHEMBL113304 | CHEMBL113310 | [(2S)-3-amino-2-hydroxypropyl](methyl)phosphinic acid
Type:
Small organic molecule
Emp. Form.:
C4H12NO3P
Mol. Mass.:
153.1167
SMILES:
CP(O)(O)CC(=O)CN
Structure:
Search PDB for entries with ligand similarity: