Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid type B receptor subunit 1
Ligand
BDBM24185
Substrate
n/a
Meas. Tech.
ChEMBL_68561 (CHEMBL679648)
IC50
16±n/a nM
Citation
 Froestl, W; Mickel, SJ; von Sprecher, G; Diel, PJ; Hall, RG; Maier, L; Strub, D; Melillo, V; Baumann, PA; Bernasconi, R Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J Med Chem 38:3313-31 (1995) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid type B receptor subunit 1
Synonyms:
GABA B | Gamma-aminobutyric acid type B receptor subunit 1 (GABA) | GABR1_RAT | Gabbr1 | Gamma-aminobutyric acid (GABA) B receptor 1 | Gb1 | GABA-B-R1 | GABA-B receptor 1 | GABA uptake | GABA-BR1 | GABA B receptor | GABABR1
Type:
Protein
Mol. Mass.:
108221.06
Organism:
Rat
Description:
Q9Z0U4
Residue:
960
Sequence:
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPALDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSETQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
  
Inhibitor
Name:
BDBM24185
Synonyms:
CGP35024 | 3-Apmpa | CHEMBL112710 | (3-aminopropyl)(methyl)phosphinic acid | SKF-97541 | 3-aminopropylphosphinic derivative, 2
Type:
Small organic molecule
Emp. Form.:
C4H12NO2P
Mol. Mass.:
137.06
SMILES:
CP(=O)(CCCN)O
Structure:
Search PDB for entries with ligand similarity: