Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50033383
Substrate
n/a
Meas. Tech.
ChEMBL_2024 (CHEMBL617319)
Kd
1.5±n/a nM
Citation
 Glen, RC; Martin, GR; Hill, AP; Hyde, RM; Woollard, PM; Salmon, JA; Buckingham, J; Robertson, AD Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT1D receptor: discovery of compounds with potential anti-migraine properties. J Med Chem 38:3566-80 (1995) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
Serotonin 1D beta receptor | Serotonin Receptor 1B | S12 | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5-HT1B | 5-HT-1B | 5-HT-1D-beta | 5HT1B_HUMAN | HTR1B | HTR1DB | Serotonin (5-HT) receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Human
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50033383
Synonyms:
(S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one | (S)-4-[3-(2-Dimethylamino-ethyl)-1H-indol-5-ylmethyl]-oxazolidin-2-one | 311C90 | CHEMBL1185 | ZOMIG | ZOMIG-ZMT | ZOLMITRIPTAN
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: