Target
Translocator protein
Ligand
BDBM50363527
Substrate
n/a
Meas. Tech.
ChEMBL_957539 (CHEMBL2378342)
Ki
5.24±n/a nM
Citation
 O'Shea, DAhmad, RÅrstad, EAvory, MChau, WFDurrant, CHirani, EJones, PAKhan, ILuthra, SKMantzilas, DMorisson-Iveson, VPassmore, JRobins, EGShan, BWadsworth, HWalton, SZhao, YTrigg, W Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents. Bioorg Med Chem Lett 23:2368-72 (2013) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50363527
Synonyms:
CHEMBL1945412 | US9481685, [18F]FE-PBR
Type:
Small organic molecule
Emp. Form.:
C22H23FN2OS
Mol. Mass.:
382.494
SMILES:
CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1ccccc1n2CCF
Structure:
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