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Target
Carbonic anhydrase 1
Ligand
BDBM50492465
Substrate
n/a
Meas. Tech.
ChEMBL_969520 (CHEMBL2406031)
Ki
4.8±n/a nM
Citation
 Güzel-Akdemir, Ö; Akdemir, A; Pan, P; Vermelho, AB; Parkkila, S; Scozzafava, A; Capasso, C; Supuran, CT A class of sulfonamides with strong inhibitory action against the α-carbonic anhydrase from Trypanosoma cruzi. J Med Chem 56:5773-81 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
Carbonate dehydratase I | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA | CA-I | CAB | CAH1_HUMAN | CA1 | Carbonic anhydrase | Carbonic anhydrase I
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Human
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM50492465
Synonyms:
CHEMBL2402767
Type:
Small organic molecule
Emp. Form.:
C14H13BrN2O3S
Mol. Mass.:
369.24
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2Br)cc1
Structure:
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