Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50492975
Substrate
n/a
Meas. Tech.
ChEMBL_976661 (CHEMBL2417036)
Ki
1.8±n/a nM
Citation
 Alleti, R; Vagner, J; Dehigaspitiya, DC; Moberg, VE; Elshan, NG; Tafreshi, NK; Brabez, N; Weber, CS; Lynch, RM; Hruby, VJ; Gillies, RJ; Morse, DL; Mash, EA Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors. Bioorg Med Chem 21:5029-38 (2013) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50492975
Synonyms:
CHEMBL2415019
Type:
Small organic molecule
Emp. Form.:
C58H83N17O11
Mol. Mass.:
1194.3869
SMILES:
CCCC[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCn1cc(CCCC)nn1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r|
Structure:
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