Target
Sodium- and chloride-dependent betaine transporter
Ligand
BDBM90787
Substrate
n/a
Meas. Tech.
ChEMBL_202584 (CHEMBL806334)
IC50
1870000±n/a nM
Citation
 Dhar, TGBorden, LATyagarajan, SSmith, KEBranchek, TAWeinshank, RLGluchowski, C Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J Med Chem 37:2334-42 (1994) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent betaine transporter
Synonyms:
Betaine transporter | S6A12_HUMAN | SLC6A12
Type:
PROTEIN
Mol. Mass.:
69366.52
Organism:
Human
Description:
ChEMBL_1454199
Residue:
614
Sequence:
MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETHL
  
Inhibitor
Name:
BDBM90787
Synonyms:
1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride | GUVACINE | Guvacine hydrochloride | MLS000859975 | SMR000326834 | cid_11957555
Type:
Small organic molecule
Emp. Form.:
C6H9NO2
Mol. Mass.:
127.1412
SMILES:
OC(=O)C1=CCCNC1 |t:3|
Structure:
Search PDB for entries with ligand similarity: