Reaction Details
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Sodium- and chloride-dependent betaine transporter
Ligand
BDBM90787
Substrate
n/a
Meas. Tech.
ChEMBL_202584 (CHEMBL806334)
IC50
1870000±n/a nM
Citation
Dhar, TG; Borden, LA; Tyagarajan, S; Smith, KE; Branchek, TA; Weinshank, RL; Gluchowski, C Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J Med Chem 37:2334-42 (1994) [PubMed] Article More Info.:
Target
Name:
Sodium- and chloride-dependent betaine transporter
Synonyms:
S6A12_HUMAN | SLC6A12 | Betaine transporter
Type:
PROTEIN
Mol. Mass.:
69366.52
Organism:
Human
Description:
ChEMBL_1454199
Residue:
614
Sequence:
MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETHL
Inhibitor
Name:
BDBM90787
Synonyms:
SMR000326834 | cid_11957555 | GUVACINE | MLS000859975 | Guvacine hydrochloride | 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C6H9NO2
Mol. Mass.:
127.06
SMILES:
OC(=O)C1=CCCNC1 |t:3|
Structure:
