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Target
Carbonic anhydrase 2
Ligand
BDBM10882
Substrate
n/a
Meas. Tech.
ChEMBL_989829 (CHEMBL2446505)
Kd
0.710000±n/a nM
Citation
 Čapkauskaitė, E; Zubrienė, A; Smirnov, A; Torresan, J; Kišonaitė, M; Kazokaitė, J; Gylytė, J; Michailovienė, V; Jogaitė, V; Manakova, E; Gražulis, S; Tumkevičius, S; Matulis, D Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII. Bioorg Med Chem 21:6937-47 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CAH2_HUMAN | CA2 | CA-II | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM10882
Synonyms:
6-ethoxy-1,3-benzothiazole-2-sulfonamide | Ethoxzolamide, EZM | Sulfonamide, 3 | CHEMBL18 | sulfonamide 3 | Ethoxzolamide (EZA) | Ethamide | Ethoxazolamide | Ethoxzolamide | US10172837, Ethoxyzolamide
Type:
Small organic molecule
Emp. Form.:
C9H10N2O3S2
Mol. Mass.:
258.01
SMILES:
CCOc1ccc2c(c1)sc(n2)S(=O)(=O)N
Structure:
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