Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50163858
Substrate
n/a
Meas. Tech.
ChEMBL_989827 (CHEMBL2446503)
Kd
5.0±n/a nM
Citation
 Čapkauskaitė, E; Zubrienė, A; Smirnov, A; Torresan, J; Kišonaitė, M; Kazokaitė, J; Gylytė, J; Michailovienė, V; Jogaitė, V; Manakova, E; Gražulis, S; Tumkevičius, S; Matulis, D Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII. Bioorg Med Chem 21:6937-47 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | Carbonate dehydratase VII | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII) | CAH7_HUMAN | CA7 | Carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Human
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50163858
Synonyms:
carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 7 | CHEMBL2443188
Type:
Small organic molecule
Emp. Form.:
C12H10ClN3O3S2
Mol. Mass.:
342.99
SMILES:
c1cnc(nc1)SCC(=O)c2ccc(c(c2)Cl)S(=O)(=O)N
Structure:
Search PDB for entries with ligand similarity: