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Target
Type-1 angiotensin II receptor
Ligand
BDBM50042534
Substrate
n/a
Meas. Tech.
ChEBML_36933
IC50
0.420000±n/a nM
Citation
 Ashton, WT; Hutchins, SM; Greenlee, WJ; Doss, GA; Chang, RS; Lotti, VJ; Faust, KA; Chen, TB; Zingaro, GJ; Kivlighn, SD Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates. J Med Chem 36:3595-605 (1994) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
Angiotensin II receptor | ANGIOTENSIN AT1 | AGTR1_RABIT | AGTR1 | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
Rabbit
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50042534
Synonyms:
2-Benzyl-5-propyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-pyrazole-3-carboxylic acid | CHEMBL334145
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCCc1nn(Cc2ccccc2)c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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