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Target
Thromboxane-A synthase
Ligand
BDBM50043283
Substrate
n/a
Meas. Tech.
ChEMBL_207794 (CHEMBL880941)
IC50
1700±n/a nM
Citation
 Yamaguchi, M; Kamei, K; Koga, T; Akima, M; Maruyama, A; Kuroki, T; Ohi, N Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones. J Med Chem 36:4061-8 (1994) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1
Type:
PROTEIN
Mol. Mass.:
59971.80
Organism:
Rattus norvegicus
Description:
ChEMBL_209768
Residue:
533
Sequence:
MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
  
Inhibitor
Name:
BDBM50043283
Synonyms:
2-Ethyl-4-pyridin-3-yl-2H-phthalazin-1-one | CHEMBL335687
Type:
Small organic molecule
Emp. Form.:
C15H13N3O
Mol. Mass.:
251.2832
SMILES:
CCn1nc(-c2cccnc2)c2ccccc2c1=O
Structure:
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