Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50043462
Substrate
n/a
Meas. Tech.
ChEMBL_35291 (CHEMBL647855)
IC50
4800±n/a nM
Citation
Dhanoa, DS; Bagley, SW; Chang, RS; Lotti, VJ; Chen, TB; Kivlighn, SD; Zingaro, GJ; Siegl, PK; Patchett, AA; Greenlee, WJ Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. J Med Chem 36:4239-49 (1994) [PubMed] Article
More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
Inhibitor
Name:
BDBM50043462
Synonyms:
CHEMBL335066 | {[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2-methyl-phenyl]-propyl-amino}-phenyl-acetic acid
Type:
Small organic molecule
Emp. Form.:
C29H34N4O2
Mol. Mass.:
470.6059
SMILES:
CCCN(C(C(O)=O)c1ccccc1)c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1C