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Target
Endothelin-1 receptor
Ligand
BDBM25761
Substrate
n/a
Meas. Tech.
ChEMBL_1539165 (CHEMBL3738809)
EC50
<5012±n/a nM
Citation
 Rombouts, FJ; Tovar, F; Austin, N; Tresadern, G; Trabanco, AA Benzazaborinines as Novel Bioisosteric Replacements of Naphthalene: Propranolol as an Example. J Med Chem 58:9287-95 (2015) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
Endothelin receptor type A | ET-A | ETA-R | hET-AR | EDNRA_HUMAN | EDNRA | ETA | ETRA | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Human
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM25761
Synonyms:
Propanolol,(+/-) | PROPRANOLOL, l- | PROPRANOLOL,(+) | PROPRANOLOL, d | PROPANOLOL(-) | PROPRANOLOL,(-) | Avlocardyl | Anapriline | [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine | CHEMBL27 | Propanolol | Propranolol
Type:
Small organic molecule
Emp. Form.:
C16H21NO2
Mol. Mass.:
259.16
SMILES:
CC(C)NC[C@@H](COc1cccc2c1cccc2)O
Structure:
Search PDB for entries with ligand similarity: