Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50500153
Substrate
n/a
Meas. Tech.
ChEMBL_1543506 (CHEMBL3750353)
IC50
0.218776±n/a nM
Citation
 Keller, M; Weiss, S; Hutzler, C; Kuhn, KK; Mollereau, C; Dukorn, S; Schindler, L; Bernhardt, G; König, B; Buschauer, A N(ω)-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([(3)H]UR-MK299) with Extended Residence Time. J Med Chem 58:8834-49 (2015) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | neuropeptide Y receptor Y1 | NPY1-R | NPY1R_HUMAN | NPY1R | NPYR | NPYY1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Human
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50500153
Synonyms:
CHEMBL3746851
Type:
Small organic molecule
Emp. Form.:
C34H38F3N9O6
Mol. Mass.:
725.73
SMILES:
Cn1cc(CNC(=O)N=C(N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1
Structure:
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