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Target
Endothelin-1 receptor
Ligand
BDBM50050001
Substrate
n/a
Meas. Tech.
ChEMBL_63356
IC50
18±n/a nM
Citation
 von Geldern, TW; Kester, JA; Bal, R; Wu-Wong, JR; Chiou, W; Dixon, DB; Opgenorth, TJ Azole endothelin antagonists. 2. Structure-activity studies. J Med Chem 39:968-81 (1996) [PubMed]  Article  BDB Entry
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | ENDOTHELIN A | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50050001
Synonyms:
5-Methyl-2-((R)-2-(1-methyl-1H-indol-3-yl)-1-{(S)-4-methyl-2-[3-(2-methyl-cyclohexyl)-ureido]-pentanoylamino}-ethyl)-1H-imidazole-4-carboxylic acid | CHEMBL366544
Type:
Small organic molecule
Emp. Form.:
C30H42N6O4
Mol. Mass.:
550.6923
SMILES:
CC(C)C[C@H](NC(=O)NC1CCCCC1C)C(=O)N[C@H](Cc1cn(C)c2ccccc12)c1nc(C(O)=O)c(C)[nH]1
Structure:
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