Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50500401
Substrate
n/a
Meas. Tech.
ChEMBL_1546324 (CHEMBL3748555)
IC50
8300±n/a nM
Citation
Colley, HE; Muthana, M; Danson, SJ; Jackson, LV; Brett, ML; Harrison, J; Coole, SF; Mason, DP; Jennings, LR; Wong, M; Tulasi, V; Norman, D; Lockey, PM; Williams, L; Dossetter, AG; Griffen, EJ; Thompson, MJ An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer. J Med Chem 58:9309-33 (2015) [PubMed] Article
More Info.:
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA