Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 4
Ligand
BDBM50500910
Substrate
n/a
Meas. Tech.
ChEMBL_1572951 (CHEMBL3801461)
Ki
16±n/a nM
Citation
 Shukla, L; Ajram, LA; Begg, M; Evans, B; Graves, RH; Hodgson, ST; Lynn, SM; Miah, AH; Percy, JM; Procopiou, PA; Richards, SA; Slack, RJ 2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. Eur J Med Chem 115:14-25 (2016) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50500910
Synonyms:
CHEMBL3799025
Type:
Small organic molecule
Emp. Form.:
C24H30Cl2N6O
Mol. Mass.:
489.441
SMILES:
Clc1ccc(CNc2ccnc(n2)N2CCC3(CCN(C3)C(=O)[C@H]3CCCN3)CC2)c(Cl)c1 |r|
Structure:
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