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Target
Kappa-type opioid receptor
Ligand
BDBM50051180
Substrate
n/a
Meas. Tech.
ChEMBL_145923
IC50
6.6±n/a nM
Citation
 Lung, FD; Collins, N; Stropova, D; Davis, P; Yamamura, HI; Porreca, F; Hruby, VJ Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2. J Med Chem 39:1136-41 (1996) [PubMed]  Article  BDB Entry
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50051180
Synonyms:
CHEMBL387083 | Cyclic Lactam Peptide Analogues of Dynorphin A(1-11)-NH2
Type:
Small organic molecule
Emp. Form.:
C61H96N20O13
Mol. Mass.:
1317.5411
SMILES:
CC[C@@H](C)[C@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCCNC(=O)C[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCCN)C(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](N)Cc1ccc(O)cc1
Structure:
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