Reaction Details Report a problem with these data
Target
60 kDa heat shock protein, mitochondrial
Ligand
BDBM50495811
Substrate
n/a
Meas. Tech.
ChEMBL_1578875 (CHEMBL1057076)
IC50
>250000±n/a nM
Citation
 Abdeen, S; Salim, N; Mammadova, N; Summers, CM; Frankson, R; Ambrose, AJ; Anderson, GG; Schultz, PG; Horwich, AL; Chapman, E; Johnson, SM GroEL/ES inhibitors as potential antibiotics. Bioorg Med Chem Lett 26:3127-3134 (2016) [PubMed]  Article  BDB Entry
Target
Name:
60 kDa heat shock protein, mitochondrial
Synonyms:
3.6.4.9 | 60 kDa chaperonin | 60 kDa heat shock protein, mitochondrial | CPN60 | Chaperonin 60 | HSP-60 | HSP60 | HSP60/HSP10 | HSPD1 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein
Type:
PROTEIN
Mol. Mass.:
61050.41
Organism:
Homo sapiens
Description:
ChEMBL_117701
Residue:
573
Sequence:
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
  
Inhibitor
Name:
BDBM50495811
Synonyms:
CHEMBL3115919
Type:
Small organic molecule
Emp. Form.:
C16H13N3O3
Mol. Mass.:
295.2927
SMILES:
Cn1c2ccccc2c(O)c(C(=O)Nc2ccncc2)c1=O
Structure:
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