Target
60 kDa heat shock protein, mitochondrial
Ligand
BDBM50495823
Substrate
n/a
Meas. Tech.
ChEMBL_1578875 (CHEMBL3813273)
IC50
>250000±n/a nM
Citation
 Abdeen, SSalim, NMammadova, NSummers, CMFrankson, RAmbrose, AJAnderson, GGSchultz, PGHorwich, ALChapman, EJohnson, SM GroEL/ES inhibitors as potential antibiotics. Bioorg Med Chem Lett 26:3127-3134 (2016) [PubMed]  Article 
Target
Name:
60 kDa heat shock protein, mitochondrial
Synonyms:
3.6.4.9 | 60 kDa chaperonin | 60 kDa heat shock protein, mitochondrial | CH60_HUMAN | CPN60 | Chaperonin 60 | HSP-60 | HSP60 | HSP60/HSP10 | HSPD1 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein
Type:
PROTEIN
Mol. Mass.:
61050.41
Organism:
Homo sapiens
Description:
ChEMBL_117701
Residue:
573
Sequence:
MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
  
Inhibitor
Name:
BDBM50495823
Synonyms:
CHEMBL3115920
Type:
Small organic molecule
Emp. Form.:
C16H11NO4S2
Mol. Mass.:
345.393
SMILES:
COC(=O)c1ccc(cc1)-c1ccc(\C=C2\SC(=S)NC2=O)o1
Structure:
Search PDB for entries with ligand similarity: