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Target
Nuclear receptor ROR-alpha
Ligand
BDBM50502410
Substrate
n/a
Meas. Tech.
ChEMBL_1807488 (CHEMBL4306847)
IC50
1585±n/a nM
Citation
 von Berg, S; Xue, Y; Collins, M; Llinas, A; Olsson, RI; Halvarsson, T; Lindskog, M; Malmberg, J; Jirholt, J; Krutrök, N; Ramnegård, M; Brännström, M; Lundqvist, A; Lepistö, M; Aagaard, A; McPheat, J; Hansson, EL; Chen, R; Xiong, Y; Hansson, TG; Narjes, F Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett 10:972-977 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-alpha
Synonyms:
NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha
Type:
PROTEIN
Mol. Mass.:
58976.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_101591
Residue:
523
Sequence:
MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM50502410
Synonyms:
CHEMBL4551507
Type:
Small organic molecule
Emp. Form.:
C19H18F6N2O4S
Mol. Mass.:
484.413
SMILES:
CCS(=O)(=O)c1ccc(cc1)C(N)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
Structure:
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