Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50054304
Substrate
n/a
Meas. Tech.
ChEMBL_28664 (CHEMBL649062)
IC50
28±n/a nM
Citation
 White, ADCreswell, MWChucholowski, AWBlankley, CJWilson, MWBousley, RFEssenburg, ADHamelehle, KLKrause, BRStanfield, RLDominick, MANeub, M Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. J Med Chem 39:4382-95 (1996) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50054304
Synonyms:
1-(2,6-Diisopropyl-phenyl)-3-(3-tetradecyl-isoxazol-5-yl)-urea | CHEMBL424655
Type:
Small organic molecule
Emp. Form.:
C30H49N3O2
Mol. Mass.:
483.729
SMILES:
CCCCCCCCCCCCCCc1cc(NC(=O)Nc2c(cccc2C(C)C)C(C)C)on1
Structure:
Search PDB for entries with ligand similarity: