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Target
Proteinase-activated receptor 2
Ligand
BDBM50503927
Substrate
n/a
Meas. Tech.
ChEMBL_1812457 (CHEMBL4311917)
IC50
100±n/a nM
Citation
 Majewski, MW; Gandhi, DM; Rosas, R; Kodali, R; Arnold, LA; Dockendorff, C Design and Evaluation of Heterobivalent PAR1-PAR2 Ligands as Antagonists of Calcium Mobilization. ACS Med Chem Lett 10:121-126 (2019) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50503927
Synonyms:
CHEMBL4470628
Type:
Small organic molecule
Emp. Form.:
C26H30FN5O4
Mol. Mass.:
495.5459
SMILES:
CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN(CC1(C)C)C(=O)CCC(O)=O)-c1ccc(F)cc1
Structure:
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