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Target
Carbonic anhydrase 12
Ligand
BDBM50504913
Substrate
n/a
Meas. Tech.
ChEMBL_1816919 (CHEMBL4316493)
Kd
0.010000±n/a nM
Citation
 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | Carbonate dehydratase XII | Tumor antigen HOM-RCC-3.1.3 | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII (CAXII) | Carbonic anhydrase XII (CA XII) | CAH12_HUMAN | CA12 | Carbonic anhydrase | Carbonic anhydrase XII
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Human
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50504913
Synonyms:
CHEMBL4436290
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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