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Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM50504917
Substrate
n/a
Meas. Tech.
ChEMBL_1816902 (CHEMBL4316476)
Kd
670±n/a nM
Citation
 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CA-VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase VA (CA VA) | Carbonate dehydratase VA | Carbonic anhydrase 5A, mitochondrial precursor | CAH5A_HUMAN | CA5A | CA5 | Carbonic anhydrase V | Carbonic Anhydrase VA
Type:
Enzyme
Mol. Mass.:
34755.54
Organism:
Human
Description:
Human (cloned) isozyme
Residue:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
  
Inhibitor
Name:
BDBM50504917
Synonyms:
CHEMBL4572161
Type:
Small organic molecule
Emp. Form.:
C19H21ClN2O5S2
Mol. Mass.:
456.97
SMILES:
COC(=O)CCCNC(=O)c1cc(c(Cl)cc1SCc1ccccc1)S(N)(=O)=O
Structure:
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